Yes and only one as boot drive. There’s no Bi-Furcation (or any 4 slots mods possible) on these motherboards (X79) for such multiple M.2 slot adapters.
An alternative is a PCIe Adapter with BIF support… a bit more expensive.
But you have a lot of PCIe slots for multiple adapters.
More info here: [REQUEST] Enable Bifurcation settings +++ on Asus Rampage IV Extreme - BIOS/UEFI Modding / BIOS Modding Guides and Problems - Win-Raid Forum (level1techs.com)
Good luck.
EDIT: For dual M.2 slot adapter read the linked post (seems that 3 can be possible?!), thats another story, a bit more easy. For an adapter with BIF support just search on the web
Definition/Requirements