The use of the ME_DIS is not for using FLASH2.EXE
The purpose of that jumper is regarding the Intel ME and access the bios regions.
Using the Intel ME9 tools, FPT tool, a dump of the bios region can be made to mod, but it needs access to write it back:
A full SPI dump backup is advisable, for safe keeping.
fptw64 -d spi.bin
Testing read/write acess to bios region:
fptw64 -bios -d bios_region.bin
Now performing the writing of the same region will let you flash it or will report FD lock.
fptw64 -bios -f bios_region.bin
If the writing is successful, the dump bios_region after NVMe mod can then be flashed.