NVMe On An Old System

I have looked at Clover EFI and that also uses a USB stick as I’m using now. Is there anyway to boot from NMVe drive without a USB stick? I’ve NEVER gone this far as it’s scary to do something like this. But then again, I have to trust someone right, might as well be someone with a screen name like yours (LOL). But will this help me boot my NMVe drive without a USB stick?