CH341 has some advantages since it’s simple and kinda ‘stupid’- it doesn’t check too much (anything?), it just does ‘something’ and works with many programs…
So if you’re aware of the caveats and check for them, it may solve some problems.
Samsung Notebook, SIO3 by design on GND, TL866 doesn’t work
CH341 still works when IO2, IO3 GND disconnected
Did you try to disconnect yellow and orange (and maybe brown)?